What is it about?
Four Schiff bases were synthesized starting from 2- Methyl Indole-3- Carboxaldehyd by condensation with substituted amines. FT-IR, 1H- nuclear magnetic resonance spectroscopy, and melting point measurements were used to analyze the structures of the produced compounds. The recently synthesized compounds have various functional groups, and as a result, they might have microbial activity. As a result, we examined these derivatives' ability to interact with different types of bacteria and fungi. The ability of the drugs under investigation to stop bacterial growth varied. Recently developed derivatives exhibit antimicrobial characteristics. In order to determine the mode of action toward the cytochrome P450-dependent enzyme fungal lanosterol 14- demethylase, molecular docking studies were carried out. According to the findings of an in vitro antifungal activity screening and docking analysis, the synthesized compounds are promising anti-Candida medicines. These drugs could function by obstructing the activity of the fungus lanosterol 14- demethylase, and they could be further developed and used as lead compounds
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Why is it important?
Applications for Schiff bases include preparing substances, identifying, detecting, and determining aldehydes or ketones, purifying carbonyl or amino compound
Perspectives
"كانت كتابة هذه المقالة تجربة ممتعة للغاية، حيث تعاونت مع زملاء في التأليف لفترات طويلة. أتاحت لي هذه المقالة فرصة للتواصل مع باحثين متخصصين في دراسة الخواص الكيميائية، مما عزز مشاركتي في أبحاث الكيمياء العضوية بشكل أكبر."
Baghdad Alyaa Jabbar ALazawi
Read the Original
This page is a summary of: Synthesis and bio-evaluation of 2-Methyl Indole-3-carboxaldehyde derivatives as potential lanosterol 14-demethylase inhibitors, January 2025, American Institute of Physics,
DOI: 10.1063/5.0255335.
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