What is it about?
An 8‐year‐old Taiwanese girl had a 6‐month history of a relapsing papulovesicular eruption on her face that resembled hydroa vacciniforme (HV). Histologically, there was a dense infiltration of large atypical lymphocytic cells expressing CD8. TCR‐γ gene rearrangement study revealed a monoclonal band present in the DNA extracted from the specimen. A diagnosis of CD8+ cutaneous T‐cell lymphoma (CTCL) was made.
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Why is it important?
To our knowledge, this is the first case of CD8+ primary CTCL with clinical features resembling HV.
Perspectives
We suggest that there is another subset of CD8+ CTCL that may present with HV-like features or develop years after HV-like diseases, and to date has been noted only in children from Asia and Mexico. The prognosis of this type of CD8+ CTCL is still unclear. The relationship between EBV, HV, and the development of CD8+ CTCL remains to be answered.
Dr. Hsuan-Hsiang Chen
National Taiwan University Hospital
Read the Original
This page is a summary of: Hydroa vacciniforme-like primary cutaneous CD8-positive T-cell lymphoma, British Journal of Dermatology, September 2002, Oxford University Press (OUP),
DOI: 10.1046/j.1365-2133.2002.04862.x.
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