Convective influx of CSF is most efficient in the midbrain

What is it about?

Cerebrospinal fluid can enter the brain along the pial-glial basement membranes of arteries by convective influx. In this project we use in-vivo imaging and quantitative electron microscopy to show that in the midbrain, alterations to the structure of pial-glial basement membranes correlates with an increase in convective influx.

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Why is it important?

These results are highly significant for the intrathecal drug delivery into the brain, indicating that the midbrain is better equipped for convective influx of CSF.