What is it about?
Leveraging advances in microfluidics and imaging technology, we setup a new paradigm of large-scale, high-content drug screening solutions for rapid biological processes, like cardiotoxicity. The designed microfluidic chips enable 10 types of drugs each with 5 concentrations to be assayed simultaneously. The imaging system RUSH has 30 Hz video rate for a centimeter filed-of-view at 0.8 μm resolution.
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Why is it important?
Experimental results demonstrated the unparallelized capability of the system in revealing the spatiotemporal patterns of Ca2+ imaging of cardiomyocytes, and validated the cardiotoxicity of certain molecules.
Perspectives
We envision this new HCS paradigm and cutting-edge platform as the most advanced alternative to well-plate based methods.
Professor Wenhui Wang
Tsinghua University
Read the Original
This page is a summary of: High content drug screening of primary cardiomyocytes based on microfluidics and real-time ultra-large-scale high-resolution imaging, Lab on a Chip, January 2022, Royal Society of Chemistry,
DOI: 10.1039/d1lc00740h.
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