What is it about?
Transport across membranes is a key phenomenon in cells. Studying this in in-vitro model systems quantitatively has significant implications. We in this work have created synthetic functional 'cells' very closely mimicking membranes of bacterium in natural conditions.
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Why is it important?
We engineer giant vesicles or synthetic 'cells' which very closely mimic bacterial membrane under range of physiological conditions. The lipid compositions and conditions used here accurately resemble bacterial membrane in natural conditions in contrary to attempted previously. Importantly, we showed the functionality and range of applications that can be carried out with these vesicles.
Perspectives
This article is my first article as an independent PI, designing of project to working with students in smooth execution of experiments is a first kind of experience. Scientifically, I find this topic quite intriguing and going through literature I realized such vesicles models have significant applications in antimicrobial field to synthetic biology to drug delivery. I really hope the models created here are easy to use in other labs for their own biophysical applications.
Harsha Bajaj
CSIR National Institute for Interdisciplinary Science and Technology (NIIST)
Read the Original
This page is a summary of: Engineering bio-mimicking functional vesicles with multiple compartments for quantifying molecular transport, Chemical Science, January 2020, Royal Society of Chemistry,
DOI: 10.1039/d0sc00084a.
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