What is it about?
A novel approach for monitoring the biomolecular interactions of superparamagnetic nanoparticles was disclosed.
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Why is it important?
In this contribution, we set out to develop an alternative analytical approach, with the aim of elucidating how fast SPIONs confront biotransformations in human serum and become converted into the protein-conjugated form in a simple and economical way. Inductively coupled plasma mass spectrometry (ICP-MS) was the method of our choice to monitor the changes in element concentrations in the nano-biosystem.
Perspectives
The ultrafiltration–ICP–MS combination proposed in this study is not limited to a given sort of nanoparticles as pertinent bio-nano interactions are followed by recording not a core metal but the biomolecular sulfur.
PhD, Doctor of Science (Chemistry) Sergei Nikolaevich Shtykov
Saratov State University
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This page is a summary of: A simple assay for probing transformations of superparamagnetic iron oxide nanoparticles in human serum, Chemical Communications, January 2019, Royal Society of Chemistry,
DOI: 10.1039/c9cc01642b.
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