What is it about?
The paper talks about use of target specific antibiotic released as a treatment strategy to modulate the gut microbiota for diet induced Type II diabetes. The paper also investigate the correlations between changes in the microbiota and insulin sensitivity and signalling, and, atthe same time, the possible mechanism that accounts for these effects.
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Why is it important?
A sugar rich diet induces inflammation and insulin resistance (IR) mainly through gut microbiota alteration. Gut dysbiosis increases lipopolysaccharide (LPS) and reduces propionate and butyrate levels to impair the insulin signalling cascades by different molecular pathways, which progresses into IR.
Perspectives
Cefdinir (Gram-negative specic) exhibited interesting diabetic preventative properties in HSD-induced diabetic rats. In addition, cefdinir intervention had prevented the progression of IR and normalized HSD-mediated gut dysbiosis by decreasing the relative copy number of Proteobacteria and Bacteroidetes. Furthermore, cefdinir treatment had decreased metabolic endotoxemia-mediated inflammation and might have activated insulin receptor signalling (IRS) by decreasing the expression of the pro-inflammatory cytokines. It had further increased the amount of the major beneficial bacteria in the gut, that is, Bifidobacteria and Clostridia, which had been found to increase the amount of butyrate in the colon. Cefdinir had induced expression of the SCFA receptor Gpr43 at the mRNA level. Thus, selective manipulation of the gut microbiota using spectrum specific antibiotics can be an emerging therapeutic strategy for the prevention of IR.
Dr Sriram Seshadri
Nirma University of Science and Technology
Read the Original
This page is a summary of: Divergent outcomes of gut microbiota alteration upon use of spectrum antibiotics in high sugar diet-induced diabetes in rats, RSC Advances, January 2018, Royal Society of Chemistry,
DOI: 10.1039/c8ra03774d.
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