A high linoleic acid diet exacerbates gut microbiota dysbiosis in T2D obese rats

What is it about?

A low n-6/n-3 ratio diet can improve blood glucose homeostasis, reduce systematic inflammation, ameliorate glomerular basal membrane thickening, reduce the expression of receptors of advanced glycation end products in renal vessel walls, and prevent diabetic nephropathies.

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Why is it important?

The high marine n-3 PUFA diet could improve blood glucose homeostasis and systematic inflammation reduction. A high marine n-3 PUFA diet ameliorated the thickness of the glomerular basal membrane and reduced the RAGE expression in the renal vessel walls. The high marine n-3 PUFA diet may exhibit protective effects against diabetic nephropathies.