What is it about?
Past literature has said that less flexible macrocycles due to the ring structure, are less able to lattice match. This leads to a less potent inhibitor. But is this true? In this work we see that macrocyclic compounds can lattice match as well as their linear counterparts. To predict inhibition a more holistic approach is needed.
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Why is it important?
Controlling crystallisation (either by inhibiting or promoting it) is important in many industrial settings. Understanding how and why certain additives impact the way they do is critical to being able to predict and design additives for specific purposes.
Perspectives
I found this work challenged my understanding of what makes a good inhibitor and sometimes we need to think about the entire system - from whether the additive will adsorb to how it adsorbs. Only when we look at the big picture can we really understand what is going on.
Dr Franca Jones
Curtin University
Read the Original
This page is a summary of: Can macrocyclic phosphonate molecules inhibit barium sulfate crystallization?, CrystEngComm, January 2019, Royal Society of Chemistry,
DOI: 10.1039/c8ce01869c.
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