What is it about?
Prednisolone is a synthetic adrenal steroid with moderately potentiated glucocorticoid activity (approximately five times that of hydrocortisone) and less than 10% of hydrocortisone's mineralocorticoid activity.
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Why is it important?
The pharmacokinetics of inhaled corticosteroids is important in relation to systemic effects. The fraction of steroid which is inhaled into the lungs acts locally on the airway mucosa, but may be absorbed from the airway and alveolar surface.
Perspectives
Proper expression of the glucocorticoid receptor (GR) plays an essential role in the development of the lung. GR expression and signalling in the lung is manipulated by administration of synthetic glucocorticoids (Gcs) for the treatment of neonatal, childhood and adult lung diseases. In lung cancers, Gcs are also commonly used as co-treatment during chemotherapy.
Dr Andre S Pimentel
Pontificia Universidade Catolica do Rio de Janeiro
Read the Original
This page is a summary of: Prednisolone adsorption on lung surfactant models: insights on the formation of nanoaggregates, monolayer collapse and prednisolone spreading, RSC Advances, January 2017, Royal Society of Chemistry,
DOI: 10.1039/c6ra28422a.
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