What is it about?
The research is focused on bis(urea) derivative that is able to interact with benzoates and other counterparts. It is interesting that only one side of bis(urea) interacts readily. Moreover, the triple complex stabilised by multiple hydrogen bonding shows the importance of preorganization.
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Why is it important?
The paper is unique because it describes rarely met phenomenon - breaking multiple, intramolecular hydrogen bonds to complex another compound intermolecularly.
Perspectives
It was a quite challenging research that was possible with a great help from computational methods. The triple complex is, in my opinion, the most interesting.
Borys Osmialowski
University of Technology and Life Sciences in Bydgoszcz
Read the Original
This page is a summary of: Conformational change in the association of a heterocyclic urea derivative forming two intramolecular hydrogen bonds in polar solvent, New Journal of Chemistry, January 2017, Royal Society of Chemistry,
DOI: 10.1039/c6nj03224a.
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