What is it about?
There has to be a balanced approach to have oxime-oxime, oxime quinoline, oxime carboxylic acid, carboxylic-acid carboxtlic acid, carboxylate-carboxylic acid or quinolinium-anion interactions in a predicable manner in cocrystals and salts.
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Why is it important?
This study clearly suggests the merits and demerits of synthon anlaysis in predesigned non-covalent synthesis. Though there is predictablity for a limited series of predesigned non-covalent synthesis of cocrystals, there are many other issues that deters to make predictablenon-covalent synthesis in general. Among the effects, (a) water-anion cluster formation, (b) anion-anion intercations, (c) change of oxime-oxime synthons, intramolecular complementing hydrogen bonds within the anionic part to adopt cyclic hydrogen bonded structure hy partially deprotonated anion, (d) partial deprotonation of specific polyprotonic acids, (e) conformational adjustments, and interplay of weaking intercations of substituent, (f) packing requirement (g) alternative homomeric or heteromeric synthon formations are predominant.
Perspectives
This provides a serious caution that the properties relating solid state based on self-assemblies involving explination of directional or non directional interpretation in bulk in material sciences and nano-assemblies or supramolecular chemistry requires very careful analysis of individual self-assemblies through structure determination. Such analysis would require predetermined structures or correct structural information through other means prior to generalisation of a property based on synthon prediction without energetic consideration and without full sceme of interplay of weak intercations. Mere suggestion based on synthon would have lesser relevance for such puroposes in absence of prior structural details.
Professor Jubaraj Bikash Baruah
IIT Guwahati
Read the Original
This page is a summary of: Oxime synthons in the salts and cocrystals of quinoline-4-carbaldoxime for non-covalent synthesis, CrystEngComm, January 2016, Royal Society of Chemistry,
DOI: 10.1039/c5ce02029h.
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