What is it about?
The high purity of the novel monomer Trt-HIS-NCA resulted to “living” polymerization and model poly(L-histidine). The influence of either leucine (LEU) or γ-benzyl-L-glutamate (BLG) randomly distributed along the PHIS chain on the pKa and degree of protonation was also studied The results indicate that it is possible to fine-tune the protonation of PHIS as a function of pH and temperature, a prerequisite for drug and gene delivery applications.
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Why is it important?
We synthesized a novel monomer to result well defined poly(L-Histidine). We showed a way to control the disruption of PHIS as a function of pH and temperature. This is extremely usefull for drug delivery applications where we want control of where the drug will be released.
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This page is a summary of: Controlled polymerization of histidine and synthesis of well-defined stimuli responsive polymers. Elucidation of the structure–aggregation relationship of this highly multifunctional material, Polymer Chemistry, January 2014, Royal Society of Chemistry,
DOI: 10.1039/c4py00687a.
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