What is it about?
Method to make 3D ECM protein patterns by fracture fabrication. Rectangular cells of different areas suspended by the ECM protein lines. Nuclear shape and cytoskeleton changes associated with this type of cell spreading.
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Why is it important?
Rectangular cells on patterned 2D surfaces are well known. But how about in more physiological 3D geometries? Our new method gives access to rectangular cells of different sizes that are spread but suspended in space and having ECM contact only at the cell periphery. Nuclear shape and cytoskeletal arrangements differ from 2D.
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This page is a summary of: Defined topologically-complex protein matrices to manipulate cell shapeviathree-dimensional fiber-like patterns, Lab on a Chip, January 2014, Royal Society of Chemistry,
DOI: 10.1039/c4lc00122b.
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