Crystal structure determination of form I of anhydrous rifampicin

What is it about?

This work describes the crystal structure determination by using X-ray powder diffraction data and an ab initio simulated annealing algorithm followed by a Rietveld refinement. Rifampicin is a first-line drug used in the treatment of tuberculosis. Several polymorphs are known to date, all of them describing solvates of rifampicin.

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Why is it important?

We determine the crystal structure of a stable form of rifampicin (form I). From now on, the identification of this polymorph in raw samples of rifampicin can be identified and, most importantly, quantified.