What is it about?

This article shows how by using Hansch analysis we were able to quantitatively determine the important molecular properties necessary to make an efficient lipid bilayer anion transporter.

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Why is it important?

Anion transport may be used as a potential future treatment for cystic fibrosis which is caused by faulty chloride and bicarbonate transport through cell membranes in the lungs. We are working to demonstrate that we can transport these anions through cell membranes in order to ameliorate the symptoms of this disease. This work is part of a larger project on anion transport.

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This page is a summary of: Towards predictable transmembrane transport: QSAR analysis of anion binding and transport, Chemical Science, January 2013, Royal Society of Chemistry,
DOI: 10.1039/c3sc51023a.
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