Cystic fibrosis treatment with alginate lyase and ciprofloxacin

What is it about?

In cystic fibrosis the lungs and intestine are clogged by microbes which are producing a gel-polymer. Administration of biodegradable pills containing a degrading gel enzyme (alginate lyase) and ciprofloxacin will improve the anticmirobial activity of the antibiotic and will reduce the side effects of the antibiotic in the patients.

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Why is it important?

We are not able to cure cystic fibrosis now, but we can improve the life quality and span of patients by increasing the treatment efficiency: the antibiotic effect in the treatment in directly associated to the ability of the molecule to reach the target: microbes that are infecting and clogging intestines and lungs forming a gel. An enzyme release form the pills (made by microspheres) will help to destroy the gel and increase the antibiotic diffusion to kill the bacteria.