What is it about?
By taking advantage of a metals ability to catalyse multiple mechanistically distinct processes, multifaceted catalysis, this work enable to direct synthesis of important compounds in a clean and efficient manner.
Featured Image
Why is it important?
First multifaceted catalysis approach to the regioselective synthesis of highly substituted pyrroles from oximes and activated alkynes. This mild and flexible method takes advantage of a gold catalysts ability to activate multiple steps of the process, thus utilising the metal more efficiently.
Read the Original
This page is a summary of: Multifaceted catalysis approach to nitrile activation: direct synthesis of halogenated allyl amides from allylic alcohols, Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry,
DOI: 10.1039/c3ob41692e.
You can read the full text:
Resources
Meet Our Authors section of Chem. Comm.
Our research was highlighted in the meet out authors section of Chemical Communications.
Link to full paper on research
Full reference: Ngwerume, S.; Lewis, W.; Camp, J. E. Development of a Gold-Multifaceted Catalysis Approach to the Synthesis of Highly Substituted Pyrroles: Mechanistic Insights via Huisgen Cycloaddition Studies. J. Org. Chem. 2013, 78, 920–934.
Link to related pyrrole synthesis from our group
Full reference: Ngwerume, S.; Camp, J. E. Synthesis of Highly Substituted Pyrroles via Nucleophilic Catalysis. J. Org. Chem. 2010, 75, 6271–6274.
Multifaceted catalysis approach to benzoxazoles
Full reference: Lester, R. P.; Camp, J. E.* Methods for the Direct Synthesis of Benzoxazoles from Halogenated Nitriles in Alcoholic Solvents. ACS Sustainable Chem. Eng. 2013, 1, 545-548.
Platinum-Catalysed Synthesis of Trichloroamidines
Full reference: Dunsford, J. J.; Camp, J. E.* Platinum-Catalysed Synthesis of Trichloroamidines. Tetrahedron Letters, 2013, 54, 4522–4523.
Gold-catalysed rearrangement of O-vinyl oximes for the synthesis of highly substituted pyrroles
Full reference: Ngwerume, S.; Camp, J. E.* Gold-Catalysed Rearrangements of O-Vinyl Oximes for the Synthesis of Highly Substituted Pyrroles. Chem. Comm. 2011, 47, 1857–1859.
The paper was Highlighted on the front cover of OBC
Contributors
The following have contributed to this page
