Adsorption of NGF and BDNF derived peptides on gold surfaces

What is it about?

The interaction between gold surfaces and two peptide fragments named NGF(1-14) and BDNF(1-12), able to mimic the proliferative activity respectively of the nerve growth factor (NGF) and the brain derived neurotrophic factor (BDNF) is studied. The physical adsorption processes on the solid surface from both single and binary peptide solutions, at physiological and acid pH, were investigated by QCM-D and CD experiments, as well as by molecular dynamics calculations.

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Why is it important?

A synergic/competitive adsorption behavior of the two peptides can be tuned by the pH change. The results are promising for the implementation of the proposed approach and systems to nanoparticles loaded with the neurotrophin-mimicking peptides, able to maintain their biological properties and pH-triggered loading and drug release processes.