What is it about?
Polymorphism, ability of a chemical compound to exist in two or more distinct crystal structures" is an important solid-state phenomenon that has tremendous implications in drug development. The current article discusses polymorphism in multi-component crystals of the type cocrystals which contain two or more solid components.
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Why is it important?
With the ever growing interest on pharmaceutical cocrystals from a drug development perspective, polymorphism in cocrystals has gained significant interest. This article reports a survey of polymorphic cocrystals and different types of polymorphs, namely synthon, conformational, packing, tautomeric, and concomitant polymorphs are discussed with representative examples. Polymorphic cocrystals that showed distinct physicochemical properties are highlighted.
Perspectives
There are a number of review articles on polymorphism in single-component crystals, however, barring some articles reporting case studies of polymorphism in cocrystals, a detailed survey of cocrystal polymorphs has not been published until publication of this article. This not only fills the knowledge gap, but also emphasize the importance of polymorphism in cocrystals.
Dr Srinivasulu Aitipamula
Institute of Chemical and Engineering Sciences
Read the Original
This page is a summary of: Polymorphism in cocrystals: a review and assessment of its significance, CrystEngComm, January 2014, Royal Society of Chemistry,
DOI: 10.1039/c3ce42008f.
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