What is it about?
Absorption spectroscopy is widely used to perform detection in lab-on-chip, which are miniaturised and integrated (bio) chemical laboratries. The micron size of channels in lab-on-chip (versus typically, a centimeter cuvette) implies that optical pathlength and hence sensitivity of absorption spectroscopy is limited based on Beer-Lambert law. We demonstrated the feasibility of increasing the optical pathlength by developing a waveguide integrated with microfluidic channel to perform absorption spectroscopy.
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Why is it important?
The ability to increase the optical pathlength without increasing the geometrical dimensions implies that sensitive measurements are performed using small sample volumes. Other nice features include ability to measure absorption in the entire visible range (that may be useful for identification), quantitative analysis, and simple operation and instrumentation.
Perspectives
We built on this work and published the following article: DOI: 10.1039/C6AN01896C, which demonstrated the feasibility of approach for pH measurement in microfluidic channels.
Dr Ruchi Gupta
University of Birmingham
Read the Original
This page is a summary of: Absorption spectroscopy in microfluidic flow cells using a metal clad leaky waveguide device with a porous gel waveguide layer, The Analyst, January 2013, Royal Society of Chemistry,
DOI: 10.1039/c2an35898k.
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