What is it about?
This manuscript describes the use of branched (tree-like) molecules to bind DNA and deliver it to cells. Future iterations of such molecules may have application in gene therapy.
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Why is it important?
The dentritic molecules are low molecular weight and biodegradable and can be cleared by the renal system. The disulfide bridge can be cleaved via reduction under biological conditions found in various cells facilitating the release of the DNA.
Perspectives
The dentritic molecules are low molecular weight and biodegradable and can be cleared by the renal system. The disulfide bridge can be cleaved via reduction under biological conditions found in various cells facilitating the release of the DNA, this was an early example from the Smith group.
Dr John George Hardy
Lancaster University
Read the Original
This page is a summary of: Synergistic effects on gene delivery – co-formulation of small disulfide-linked dendritic polycations with Lipofectamine 2000™, Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry,
DOI: 10.1039/b818469k.
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