What is it about?
We testify that the viscosity of sheath flow is the key to the performance of sheath constriction (SC), and propose to employ non-conductive viscous sheath flow in SC to unlock the tradeoff between sensitivity and throughput in impedance flow cytometry (IFC), while ensuring the measurement accuracy. Then, accurate and clogging-free IFC based on viscous non-conductive sheath flow is presented with improved performance in throughput, SNR, and sensitivity for single cell electrical property measurement, which paves the way for IFC to be really usable in practice.
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Why is it important?
We propose to employ non-conductive viscous sheath flow in SC to unlock the tradeoff between sensitivity and throughput, while ensuring the measurement accuracy. Clogging can be avoided via sheath flow, which is desirable in practical use.
Perspectives
We envisioned that viscous SC IFC paves the way for IFC to be really usable in practice with clogging-free, accurate, and sensitive performance
Professor Wenhui Wang
Tsinghua University
Read the Original
This page is a summary of: Performance-enhanced clogging-free viscous sheath constriction impedance flow cytometry, Lab on a Chip, January 2023, Royal Society of Chemistry,
DOI: 10.1039/d3lc00178d.
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