What is it about?
This study examines how different-shaped macromolecular crowders (dextran-40, ficoll-70, PEG-35) affect the unfolding of human serum albumin (HSA). Rod-shapped Dextran-40 and spherical ficoll-70 stabilize HSA while mesh PEG-35 destabilizes it mainly through entropic effects.
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Why is it important?
This study explores how different-shaped molecules affect protein behavior, mimicking crowded cell environments. It helps us understand protein stability, folding and conformotional dynamics, which is crucial for developing new drugs and treatments.
Read the Original
This page is a summary of: Macromolecular crowding: how shape and interaction affect the structure, function, conformational dynamics and relative domain movement of a multi-domain protein, Physical Chemistry Chemical Physics, January 2022, Royal Society of Chemistry,
DOI: 10.1039/d1cp04842b.
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