What is it about?
Heparin-imprinted synthetic polymer surfaces with the ability to attenuate activation of both the complement and the coagulation system in whole blood were successfully produced. Imprinting was achieved using a template coated with heparin, a highly sulfated glycosaminoglycan known for its anticoagulant properties.
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Why is it important?
The observed low thrombogenicity of this copolymer combined with the attenuation of complement activation induced by the molecular imprint offer potential for the development of self-regulating surfaces with important potential clinical applications.
Perspectives
Open access free download paper.
Dr James R Smith
University of Portsmouth
Read the Original
This page is a summary of: Heparin molecularly imprinted surfaces for the attenuation of complement activation in blood, Biomaterials Science, January 2015, Royal Society of Chemistry,
DOI: 10.1039/c5bm00047e.
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