Ion substitution to impact on the physicochemical properties of a drug compound.

What is it about?

We have explored the solid state of methylmethcathione hydrochloride and it's bromide analogue. The bromide salt has two polymorphic forms at ambient temperature and pressure whereas the chloride form undergoes a phase transformation at low temperature. This study explored the effect of substituting varying quantities of bromide ion to observe the effect on the phase transition temperature.

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Why is it important?

The ability to alter the physicochemical properties with minimal chemical adaptation could be utilised without major impact on the processing of the materials. This might be important in the case of materials that undergo phase transformations at the temperature of processing which would cause problems for the manufacturer. If this solid could be adapted so that the phase transition could be moved away form the processing temperature or indeed suppressed then this would provide a very convenient method to change the solid for production