What is it about?
The manuscript proposes a simple and general explanation of why, and under what conditions porous materials can induce protein crystal nucleation.
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Why is it important?
This theoretical work has practical application, as it will allow the rational design of more highly optimized porous nucleation-inducing materials for protein crystallization.
Perspectives
A wide range of disciplines require crystal structures of proteins in order to understand biological pathways, enable rational design of new and improved medicines and for a variety of agricultural, biotechnological and chemical processes. Obtaining high-quality crystals is a major bottleneck to structure determination, hence there is an urgent need for new and improved means to facilitate their growth. A promising way to do that is to use materials with special properties, that can act as protein crystallization promoters by inducing nucleation of protein crystals.
Professor Naomi Esther Chayen
Imperial College London
Read the Original
This page is a summary of: Protein crystal nucleation in pores, Scientific Reports, January 2017, Nature,
DOI: 10.1038/srep35821.
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