What is it about?
What is a splice signal? What determines the strength of a splice signal? How can the splice strength affect alternative splicing? How selection and mutation operate on the splicing signals in diverse vertebrate lineages? Can exon skipping be explained by weak splicing sites flanking it? How can splicing site strength be quantified? This paper uses both experimental and bioinformatic approaches to address these questions.
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Why is it important?
The approach and experimental results suggest that alternative splicing is predictable.
Perspectives
What is a splice signal? What determines the strength of a splice signal? How can the splice strength affect alternative splicing? How selection and mutation operate on the splicing signals in diverse vertebrate lineages? Can exon skipping be explained by weak splicing sites flanking it? How can splicing site strength be quantified? This paper uses both experimental and bioinformatic approaches to address these questions.
Prof. Xuhua Xia
University of Ottawa
Read the Original
This page is a summary of: Selection preserves Ubiquitin Specific Protease 4 alternative exon skipping in therian mammals, Scientific Reports, February 2016, Nature,
DOI: 10.1038/srep20039.
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