What is it about?
Cancer associated fibroblasts modify tumor microenvironment (via MCP-1 and SDF-1 cytokines) in a way that suppresses immune system.
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Why is it important?
Cancer associated fibroblasts (CAFs) seem to play pivotal roles in sculpturing the tumour microenvironment in breast cancer, and therapeutic strategies to reverse the CAF-mediated immunosuppressive microenvironment should be taken into consideration.
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This page is a summary of: Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1+ TAMs, Scientific Reports, February 2019, Springer Science + Business Media,
DOI: 10.1038/s41598-019-39553-z.
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