What is it about?
Quantification of left ventricular (LV) structure and function plays an important role in evaluation of cardiovascular disease. Traditionally, simple measurements of the left ventricle such as LV mass and LV volume are reported from cardiac imaging and a more global representation of the heart shape is not available. We constructed two statistical shape models of left ventricle which represent global LV morphology. The regression analyses revealed that the principal components derived from these shape models have stronger associations with cardiovascular risk factors than conventional measurements such as LV mass or LV volume.
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Why is it important?
This is the first paper to compare and contrast two statistical shape models (constructed using different techniques) and shows that they have robust relationships with cardiovascular risk factors.
Perspectives
These shape models may play an important role in understanding the influence of cardiovascular risk factors on cardiac structure and function. They may also contribute in creating improved risk prediction models.
Nay Aung
Queen Mary University of London
Shape models of the left chamber of the heart show differences with known risk factors for heart attacks. This approach is promising for the early detection of disease.
Professor Steffen E Petersen
Queen Mary University of London
Read the Original
This page is a summary of: Independent Left Ventricular Morphometric Atlases Show Consistent Relationships with Cardiovascular Risk Factors: A UK Biobank Study, Scientific Reports, February 2019, Springer Science + Business Media,
DOI: 10.1038/s41598-018-37916-6.
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