What is it about?
This publication details the effect of M. bovis infection on methylation patterns in host lung immune cells, alveolar macrophages. DNA methylation is involved with gene regulation. Upon infection many host immune genes are ramped up to combat infection, therefore we hypothesised that DNA methylation might have a role in this. We show that no differences are observed between infected and control and conclude that DNA is not reprogrammed to facilitate the wide changes in gene expression 24 hours following infection.
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Why is it important?
This is an important study as it is the first to document genome wide DNA methylation during host-pathogen interaction and it is one of the first papers outlining the whole genome bisulfite sequencing method (WGBS) in bovine/cattle.
Read the Original
This page is a summary of: The bovine alveolar macrophage DNA methylome is resilient to infection with Mycobacterium bovis, Scientific Reports, February 2019, Springer Science + Business Media,
DOI: 10.1038/s41598-018-37618-z.
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