What is it about?
N-mono-alkylation and N,N-hetero-dialkylation are both possible under ambient photocatalytic conditions using alcohols as alkylating agents! Heterogeneous mixed-metal-loaded semiconductor photocatalysis does not mandate the formation of (metal) salt waste byproducts!
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Why is it important?
CH3OH and other alcohols are sustainable carbon resources, available by reduction of renewable resources including carboxylic acid derivatives. The reaction rate of this N-alkylation using alcohols is very rapid, not mandating the formation of salt wastes, easily to purify the N-methylation products, the last stage N-methylation of pharmaceuticals are also possible, and thus has potential for application in positron emission tomography (incorporation of C[11] whose half life-time is ca. 20 min), in which C[11]H3OH should be used.
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This page is a summary of: N-Alkylation of functionalized amines with alcohols using a copper–gold mixed photocatalytic system, Scientific Reports, May 2018, Springer Science + Business Media,
DOI: 10.1038/s41598-018-25293-z.
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