What is it about?
Many viral polymerases function on the membrane where they are somehow recruited. We show that the negative charge from lipids and membrane tethered 3B protein recruit the viral RNA polymerase together.
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Why is it important?
It was believed that the negative lipid PI4P (phosphatidylinositol 4-phosphate) recruits picornaviral polymerases to the membrane. Here we show that the process is very inefficient but becomes efficient when a viral membrane-tethered 3B protein is present (in infected cells it always is in the form of the fusion membrane 3AB protein).
Perspectives
Perhaps, we finally understand how viruses manipulate our cells to recruit their polymerase to their sites of replication.
Evzen Boura
Institute of Organic Chemistry and Biochemistry
Read the Original
This page is a summary of: Negative charge and membrane-tethered viral 3B cooperate to recruit viral RNA dependent RNA polymerase 3D
pol
, Scientific Reports, December 2017, Nature,
DOI: 10.1038/s41598-017-17621-6.
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