What is it about?
Treatment of bacterial lung infections is hampered by delivering the therapeutic compound to the site of infection. In addition, the increasing incidence of antibiotic resistance and the inflammation associated with lung infection can further complicate therapy. In this paper we provide some evidence that a, so-called, host defense peptide from chicken lungs help with the infection and inflammation. Furthermore, this peptide can be combined with exogenous surfactant, which is a material that can help it deliver to the lung, while maintaining most of its therapeutic efficacy.
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Why is it important?
Antibiotic resistance is a global health threat that requires the investigation into novel approaches to combat bacterial infection. This paper describes one such approach specifically targeting lung infections. Further research is required to further explore this novel therapeutic approach.
Perspectives
Fun fact: this publication is one of three co-authored papers with my brother Edwin
Dr Ruud Veldhuizen
Western University
Read the Original
This page is a summary of: The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens, Scientific Reports, November 2017, Springer Science + Business Media,
DOI: 10.1038/s41598-017-15558-4.
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