What is it about?
we present in this paper a new method employing a micro-nano-device that is capable of monitoring the dynamic cell-substrate attachment process at single cell level in real time without labeling.
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Why is it important?
The experiment results show that the single cell attachment process of both HeLa and C3H10 cells follow the logistic retarded growth model, but with different kinetic parameters. Variations in spectral shift during the same culture period across single cells present new evidence for cell heterogeneity.
Perspectives
The micro-nano-device provides a new, label-free, real-time, and sensitive, platform to investigate the cell adhesion kinetics at single cell level.
Professor Wenhui Wang
Tsinghua University
Read the Original
This page is a summary of: Label-free and real-time monitoring of single cell attachment on template-stripped plasmonic nano-holes, Scientific Reports, September 2017, Springer Science + Business Media,
DOI: 10.1038/s41598-017-11383-x.
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