What is it about?
Ramachandran distributions tell us the secondary structural trends of amino acids. These maps contain historical information of their molecular evolution. We report a novel correlation with replacement matrices used in bioinformatics.
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Why is it important?
We propose that the correlation obeys two optimal-efficiency principles: (a) interchangeability between amino acids occurs by preserving secondary structural propensity, and (b) the mutability of an amino acid depends directly on its mass, and inversely with its frequency.
Perspectives
These findings may guide future developments on replacement matrices used in sequence alignments.
Dr Hugo J Bohorquez
Fundacion Instituto de Inmunologia de Colombia
Read the Original
This page is a summary of: Mass & secondary structure propensity of amino acids explain their mutability and evolutionary replacements, Scientific Reports, August 2017, Nature,
DOI: 10.1038/s41598-017-08041-7.
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