What is it about?
This article explains reduced epithelial thickness in Oral submucous fibrosis tissues through the reduced proliferative activity of basal stem cells, while hyperplastic e[pithelium results from the increased proliferative activity, which is mirrored in the expression of stem markers in these two tissues.
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Why is it important?
Challenges the conventional thinking about Oral submucous fibrosis pathogenesis.
Perspectives
Gene expression pattrerns fits well in this framework of and needs to be further experimentally tested, which might lead to a better understanding of the disease.
Professor Mohit Sharma
SGT Dental College Hospital & Research Institute
Read the Original
This page is a summary of: Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation, International Journal of Oral Science, August 2020, Springer Science + Business Media,
DOI: 10.1038/s41368-020-00090-5.
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