First Hematological Signals of Latent Anemia to Aging Population

What is it about?

Anemia is an independent risk factor for morbidity and mortality in an array of disorders common to seniors including cancer, renal diseases and heart diseases. The aim of this study was to identify the first hematological signals of latent anemia to aging population using as screening the hematological aspects of cells from peripheral blood and additional tests, establishing the etiology of anemia in the elderly. Method_: Additional to level of hemoglobin(HGB) and hematocrit (HCT) have been included Hematological Indexes( MCV, HCV, MCHC ), red cell distribution width,(RDW), reticulocyte count (RET), serum iron (SI), total iron binding capacity,(TIBC), transferrin saturation index, (TSI), serum ferritin( SF), on an study of 140 adult hospitalized patients, in wars with chronic diseases males and females with ages past 65 years.

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Why is it important?

esults_: Anemia of chronic diseases (ACD) is more common in the elderly than other group. In ACD correlation of hematological testes was following: 32 % with normal HGB, HCT and normal hematological indexes, 21.5 % with only MCV or HCV decreased, 22.5 % patients with HB in value 10.8 g/dl for women and 11.08 g/dl form men, 15 % patients with HB 9.8-10.6g/d L and 9% patients with HB 7.8-9.6, g/d L (mean SD=2,2 ); average number of Reticulocytes =1.2%; Corrected Index Ret = 0.6%; Production Index Reticulocytes, (PIR) = 1.4, meaning the hypo-regenerative anemia with globular value, GV =1.2. Precision: CV < 2% for RBC, CV < 1% for HB and CV < 2% for HCT. Accuracy: R > 0.95 for RBC, HGB and HCT. In this study was observed a higher prevalence of anemia in elderly men than in women. Anemia of renal disease is considered to be a distinct form of anemia and is typical due to decreased EPO production in 20 percent from normal value to adult persons.

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