Physical nature of the control of cell cycle entry

What is it about?

The article provides a quantitative and physical foundation for understanding cell cycle entry, the dysregulation of which results in cancer development.

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Why is it important?

1. It challenges the textbook view of fundamental mechanism underlying cell cycle control and is is a paradigm shift. 2. It explored the chemical kinetics of Rb/E2F network activation to quantitatively define the control logic of cell cycle entry. 3. The methodology will apply to the study of other gene regulatory networks.