What is it about?
This publication and the accompanying one in Nature provide the detailed 3D structure of a receptor that plays a key role in platelet activation and blood clotting. Binding sites for antithrombotic drug molecules and nucleotides that are similar to the endogenous agonist are revealed.
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Why is it important?
This new understanding about the plasticity of the receptor will not only deepen understanding of activation of this receptor super-family, but will also provide invaluable insight into the improvement and development of P2Y12 drugs targeting cardiovascular and other diseases.
Read the Original
This page is a summary of: Structure of the human P2Y12 receptor in complex with an antithrombotic drug, Nature, March 2014, Springer Science + Business Media,
DOI: 10.1038/nature13083.
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