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Why is it important?
Inherited defects in MC1R are a well-known melanoma risk determinant. We are discovering how MC1R function controls melanocyte DNA repair and in so doing, identifying potential ways to prevent UV mutations and lower melanoma risk.
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This page is a summary of: Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes, Journal of Investigative Dermatology, December 2015, Elsevier,
DOI: 10.1038/jid.2015.280.
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