What is it about?
Cold piezoelectric plasma (CPP) is a novel approach to cancer therapy, offering portable treatment options to induce cancer cell death. This study evaluates CPP’s effectiveness against cholangiocarcinoma (CCA), a highly aggressive biliary cancer, using corona discharge (Pz-CD) and dielectric barrier discharge (Pz-DBD) in vitro. Both methods produce reactive species and cause temperature gradients, with Pz-CD delivering higher power. CPP induces actin cytoskeleton remodeling, DNA damage, and cell death, highlighting its potential as a promising antitumor therapy.
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Photo by National Cancer Institute on Unsplash
Why is it important?
This article is important because it pioneers the application of cold piezoelectric plasma (CPP) in treating cholangiocarcinoma, a highly aggressive and treatment-resistant cancer. By demonstrating its dual mechanisms—immediate cytoskeleton remodeling and long-term DNA damage induction—it highlights CPP's potential as a localized, non-invasive, and effective antitumor therapy. This study paves the way for innovative, portable plasma devices in oncology while emphasizing safety and minimizing side effects, addressing a significant gap in cancer treatment approaches.
Perspectives
This study offers a groundbreaking approach to cancer therapy using cold piezoelectric plasma (CPP), particularly for cholangiocarcinoma, an aggressive and hard-to-treat cancer. Personally, I find this research inspiring due to its focus on developing localized, portable, and non-invasive treatment methods. By showing how CPP induces targeted DNA damage and cytoskeleton remodeling without major disruptions to cell membranes, it presents a safer, more precise alternative to conventional therapies. This innovative direction could redefine cancer treatment standards.
Dr Thierry Dufour
Read the Original
This page is a summary of: Targeting cholangiocarcinoma cells by cold piezoelectric plasmas: in vitro efficacy and cellular mechanisms, Scientific Reports, December 2024, Springer Science + Business Media,
DOI: 10.1038/s41598-024-81664-9.
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