What is it about?
ADNP mutations cause ADNP syndrome strongly related to autism. We found that Adnp functions in the developing cerebral cortex in mice.
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Why is it important?
We found that Adnp plays an important role in neuritogenesis, spinogenesis, neural connectivity and neural activity. Additionally, we were able to identify the mechanisms by which Adnp distribution in neurons changes from the nucleus to the cytoplasm during neuronal differentiation via Adnp phosphorylation and binding to 14-3-3.
Perspectives
I hope these findings provide an opportunity to understand in vivo Adnp functions and the etiology of ADNP syndrome and ASD.
Kazuhito Toyooka
Drexel University
Read the Original
This page is a summary of: The cytoplasmic localization of ADNP through 14-3-3 promotes sex-dependent neuronal morphogenesis, cortical connectivity, and calcium signaling, Molecular Psychiatry, January 2023, Springer Science + Business Media,
DOI: 10.1038/s41380-022-01939-3.
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