What is it about?
The HMBC experiment while very widely employed in structure elucidation protocols is at a disadvantage when optimized for very small long-range heteronuclear couplings. At the end of the expeirment, the magnetization is antiphase and when the absolute value spectrum is calculated for presentation the antiphase components can self-cancel preventing the correlation from being observed. LR-HSQMBC, in contrast, is specifically optimized for very long-range heteronuclear correlations. Magnetization is refocused and decoupling can be applied. Hence, while HMBC can "reach out" 3 and only occasionally 4 bonds, in contrast, the LR-HSQMBC experiment routinely affords 4, 5, and often 6 bond correlations. The LR-HSQMBC experiment should be employed AFTER interpreting the HMBC data.
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Why is it important?
LR-HSQMBC provides the means of accessing very long-range heteronuclear correlations that cannot be observed using the HMBC experiment.
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This page is a summary of: LR-HSQMBC: A Sensitive NMR Technique To Probe Very Long-Range Heteronuclear Coupling Pathways, The Journal of Organic Chemistry, April 2014, American Chemical Society (ACS),
DOI: 10.1021/jo500333u.
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