Publication
Discovery of 4-Morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the 6-Aryl Substituent
Jeroen C. Verheijen, David J. Richard, Kevin Curran, Joshua Kaplan, Mark Lefever, Pawel Nowak, David J. Malwitz, Natasja Brooijmans, Lourdes Toral-Barza, Wei-Guo Zhang, Judy Lucas, Irwin Hollander, Semiramis Ayral-Kaloustian, Tarek S. Mansour, Ker Yu, Arie Zask
Journal of Medicinal Chemistry, November 2009, American Chemical Society (ACS)
DOI: 10.1021/jm9013828