What is it about?
This manuscript describes branched (tree-like) molecules displaying multiple copies of a naturally occurring polyamine (spermine) that enable it to bind DNA, and preliminary studies of their efficacy at transferring DNA across a cell membrane.
Featured Image
Why is it important?
This was an early example of such structures employing spermine as the DNA-binding motif, and highlighted the need for further development.
Perspectives
This was an early example of such structures employing spermine as the DNA-binding motif, and highlighted the need for further development by the Smith and Kostiainen groups.
Dr John George Hardy
Lancaster University
Read the Original
This page is a summary of: Dendrons with Spermine Surface Groups as Potential Building Blocks for Nonviral Vectors in Gene Therapy, Bioconjugate Chemistry, January 2006, American Chemical Society (ACS),
DOI: 10.1021/bc050212r.
You can read the full text:
Resources
Contributors
The following have contributed to this page
