What is it about?
synthesis and characterization of polymeric PLGA nanoparticles (NPs) that are surface decorated with sugar-based ligand, and that can be used as smart nano-biomedical-devices for targeted drug delivery to tumor cells
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Why is it important?
Targeting the nanodevice to specific tissue such as a tumor, is particularly important when highly cytotoxic drugs, such as those used in chemotherapy treatments are used. The insertion of the drug in a nanocarrier, reaching preferentially tumor tissue, can reduced the severe side effects and cytotoxicity toward healthy tissue.
Perspectives
Develop novel and more effective therapeutic agents
Barbara La Ferla
University of Milano-Bicocca
Read the Original
This page is a summary of: Glycofunctionalization of Poly(lactic-co-glycolic acid) Polymers: Building Blocks for the Generation of Defined Sugar-Coated Nanoparticles, Organic Letters, May 2018, American Chemical Society (ACS),
DOI: 10.1021/acs.orglett.8b01287.
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