What is it about?
a straightforward and rapid synthesis of(±)-tapentadol was achieved, with better diastereoselectivity,from totally different and commercially relevant raw materials.
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Why is it important?
The synthetic operation from cheaply available tetrahydrothiopyr-an-4-one provided an added advantage of scale up at a lower cost than the acyclic strategy.
Perspectives
higher diastereoselectivity was obtained as compared with previous routes
Dr. Kranthi Kumar Ramagonolla
Harvard University
Read the Original
This page is a summary of: Tetrahydrothiopyran-4-one as Five-Carbon Source for Scalable Synthesis of (±)-Tapentadol, Organic Process Research & Development, June 2019, American Chemical Society (ACS),
DOI: 10.1021/acs.oprd.9b00121.
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