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An operationally simple sodium iodide mediated C-S and C-Se bond formation protocol involving substituted 4-quinolone and thiols/diselenide to generate different ArS/ArSe substituted 4-quinolone derivatives in excellent yields was developed. The versatility of this methodology has been successfully demonstrated by extension of the suitable reaction conditions to the both substrates having different substituents. This regioselective C-H bond activation approach provides a direct access of structurally diverse 3-sulfenylated/selenylated 4-quinolone derivatives. Moreover, this new method proceeds without transition metal catalyst and pre-requisite NH-protection of 4-quinolone derivatives.
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This page is a summary of: Generation of ArS and ArSe substituted 4-quinolone derivatives using sodium iodide as an inducer, The Journal of Organic Chemistry, September 2018, American Chemical Society (ACS),
DOI: 10.1021/acs.joc.8b01426.
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