What is it about?
The reaction of peroxynitrite with carbon dioxide yields to some extent the very reactive nitrogen dioxide and trioxidocarbonate(·1-) radicals. What we answered is the question to what extent. At lower concentrations one finds a yield of about 30%, at higher concentrations it can be as low as 5%. We provided a mechanism that explains these different yields.
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Why is it important?
As carbon dioxide and peroxynitrite occur in vivo, one wants to know what the yield of radicals is. Given the concentration of carbon dioxide in vivo, the yield might be about 20%.
Perspectives
The publication of our mechanism hopefully ends a long controversy in the literature. We do not plan to pursue this further.
Professor Willem H. Koppenol
Swiss Federal Insitute of Technology (ETH)
Read the Original
This page is a summary of: Thinking Outside the Cage: A New Hypothesis That Accounts for Variable Yields of Radicals from the Reaction of CO2 with ONOO–, Chemical Research in Toxicology, May 2020, American Chemical Society (ACS),
DOI: 10.1021/acs.chemrestox.9b00309.
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